The Peale family is best known as a family of artists; however, family interests and activities were much more wide-ranging. The best known Peale is Charles Willson Peale (1741-1827, APS 1786), who produced more than one thousand paintings, including hundreds of portraits of leading Americans during the colonial and early national periods. Peale was married three times, to Rachel Brewster (1744-1790), Elizabeth de Peyster (1765-1804), and Hannah More (1755-1821). He had eighteen children, eleven of whom reached adulthood. Three of Charles Willson Peale's sons became artists: Raphaelle Peale (1774-1825), Rembrandt Peale (1778-1860), and Rubens Peale (1784-1865). A fourth son, Titian Ramsay Peale (1799-1885, APS 1833), was a naturalist (who made drawings on the exploring expeditions he accompanied) and pioneer in photography, and another son, Benjamin Franklin Peale (1795-1870), became a naturalist and paleontologist. Peale's daughter Sophonisba Angusciola was married to Coleman Sellers (1781-1834), an inventor and manufacturer of machinery, including locomotives. Two of their sons, George Escol Sellers (1808-1899) and Coleman Sellers (1827-1907, APS 1872), were inventors and engineers. The latter served as director of the construction of the hydro-electric power development at Niagara Falls. He was married to Cornelia Wells Sellers (1831-1909). One of their grandsons was Charles Coleman Sellers (1903-1980, APS 1979), a librarian and historian and the author of several studies of the Peale family, including a Charles Willson Peale biography.

An important 18th century radical republican theorist and political writer, Thomas Paine was a leading figure in the American Revolution. Despite his humble beginnings and lack of formal education, his reasoned and persuasive writings not only influenced nascent American republican ideology, but profoundly affected the perception of government in England and France as well. His three most influential works are Common Sense (1776), The Rights of Man (1791-1792), and The Age of Reason (1794, 1795, 1807). The Richard Gimbel Collection is a heterogeneous mix of items connected only by the fact that they were all collected by Gimbel (1898-1970) and that most were written by, to, or about the revolutionary Paine. Of primary importance are the approximately sixty-five letters or manuscripts in Paine's own hand, including Paine's 1776 manuscript notes for Common Sense, his letter of January 10, 1781, in which he takes leave of his former commanding officer, Nathanael Greene, and his January 6, 1789 letter to Kitty Nicholson Few, in which he writes of his view of matrimony and other personal matters. The collection includes a series of correspondence between Thomas Paine and Samuel Adams, which were originally marked "forgeries," these appear instead simply to be the letters of two men bearing famous names.